Bone matrix proteins in osteogenesis and remodelling in the neonatal rat mandible as studied by immunolocalization of osteopontin, bone sialoprotein, α2HS-glycoprotein and alkaline phosphatase
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2019, Pathology Research and PracticeCitation Excerpt :The protein was also present in osteoid, particularly in cases of Cemento-osseous Dysplasia and Fibrous Dysplasia. Although some authors had reported absence of expression [11,20], others show positivity in osteoid, even weak [26,33]. Osteoblasts represent the cellular type that expresses the highest levels of BSP [14,20,21,22,24], mostly when they exhibit cuboidal morphology and are depositing matrix [23].
High metabolic activity of tissue-nonspecific alkaline phosphatase not only in young but also in adult bone as demonstrated using a new histochemical detection protocol
2018, General and Comparative EndocrinologyCitation Excerpt :Once the bone matrix is mineralised, TNAP activity is inhibited and can no longer be demonstrated histochemical (Wergedal and Baylink, 1969; Bonucci et al., 1992). Thus, whilst other non-collagenous proteins such as osteopontin and bone sialoprotein appear later and continue to be expressed in lining cells and osteocytes (Weinreb et al., 1990; Pinero et al., 1995), TNAP has served so far as an early marker of osteolineage cells, e.g., in the search for novel tools in regenerative medicine (Ochiai-Shino et al., 2014). In light of the growing population of elderly people, research on osteoporosis and other skeletal metabolic diseases have increasingly gained importance (WHO, 2007; Ochiai-Shino et al., 2014).
In vitro human periodontal ligament-like tissue formation with porous poly-l-lactide matrix
2013, Materials Science and Engineering CBiological implications of fetuin for bone remodeling system and possible evidence for its use in heterotopic ossification
2012, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologySeparation of newly formed bone from older compact bone reveals clear compositional differences in bone matrix
2011, BoneCitation Excerpt :With the exception of in situ hybridization, all of the above mentioned biochemical approaches provided accurate quantitative assessments, but not a determination of tissue or histological location for these non-collagenous proteins. Immunostaining of non-collagenous proteins in bone has indicated specific patterns for their accumulation in osteoid, along the mineralization front of bone, and within more mature bone [11–13]. In particular, these studies showed that bone sialoprotein or osteopontin appeared to be highly accumulated along the mineralization front of bone, which is a location containing newly formed woven bone.
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