Lactate and pyruvate transport is dominated by a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles
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Intervention on lactate in cancer: A promising approach for the development of cancer therapeutics
2022, Advances in Cancer Biology - MetastasisThe tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
2020, Journal of Sport and Health ScienceCitation Excerpt :Immunohistologic evidence of the presence of mLOC is presented in Fig. 7. At the time of discovery, it was known that, while lactate was preferred over pyruvate as an oxidizable substrate, monocarboxylate transporters (MCTs) could also transport pyruvate and β-hydroxybutyrate,86,87 but a unique mitochondrial pyruvate transporter had not been identified. Following reports of discovery of the mitochondrial pyruvate carrier (mPC),88,89 and with access to our own custom antibodies to MCT1 as well as commercially available antibodies to the putative mPC, we obtained images assessing co-localization of MCT1 and mPC in L6 cells.
Lactic acid and its transport system
2020, An Innovative Approach to Understanding and Treating Cancer: Targeting pH: From Etiopathogenesis to New Therapeutic AvenuesThe Science and Translation of Lactate Shuttle Theory
2018, Cell MetabolismCitation Excerpt :Relevant to lactate shuttling in brain (Barros, 2013; Bélanger et al., 2011), neurons possess the cellular components necessary for glucose uptake and use by an intracellular lactate shuttle (Hashimoto et al., 2008), and a post-trauma neuroprotective role of lactate has been proposed (Holloway et al., 2007; Schurr and Gozal, 2012). From the earliest work on plasma membrane lactate exchange, it was recognized that lactate transporters are symporters moving solute down anion and proton concentration gradients (Roth and Brooks, 1990a, 1990b), which is consistent with more recent studies, for example between astrocytes and neurons (Mächler et al., 2016). Hence, it is not surprising that Bellen and colleagues (Liu et al., 2017) have described a neuron-glia lactate shuttle linked to lipid transfer that may be disrupted in Alzheimer’s disease (Bailey et al., 2015).