Keratoepithelioplasty
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Cited by (152)
Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets
2022, Stem Cell ReportsCitation Excerpt :LSCD treatment is a prominent issue. Corneal limbal transplantation (LT) (Thoft, 1984) using a donor cornea containing the corneal epithelium, stroma, keratocytes, and antigen-presenting cells (APCs), has been conventionally performed to treat LSCD. However, a shortage of donor corneas (Gain et al., 2016) limits the opportunity for LT, and rejection owing to the mixed cell types, including donor APCs, negatively affects clinical outcomes (Ilari and Daya, 2002).
Challenges in the management of bilateral eyelid closure in Stevens-Johnson Syndrome
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :Ocular surface reconstruction in SJS cases is challenging, and various surgical methods have previously been reported.14,18,36–39 Thoft introduced limbal stem cell transplantation or keratoepithelioplasty, and it can successfully be combined with symblepharon surgery.39,40 MMG is indicated in cases of lid-margin keratinization, which directly addresses the problem by surgically improving the surface of the posterior lid margin.17
Stem cells in the eye
2020, Principles of Tissue EngineeringLong-term Outcomes of Ocular Surface Stem Cell Allograft Transplantation
2017, American Journal of OphthalmologyLimbal stem cell deficiency management. A review
2016, Journal Francais d'OphtalmologieContact Lens-induced Limbal Stem Cell Deficiency
2016, Ocular Surface
This study was supported in part by Research Grants RO1-EY01830 and RO1-EY 04205 from the National Eye Institute and in part by the Lions Eye Research Fund, Inc.
Reprint requests to Richard A. Thoft, M.D., Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114.