Placental transfer of indomethacin in the human pregnancy
References (14)
- et al.
Neonatal outcome after indomethacin treatment for preterm labor
Am J Obstet Gynecol
(1986) - et al.
Fetal and neonatal effects of Indomethacin used as a tocolytic agent
Am J Obstet Gynecol
(1985) - et al.
Indomethacin-placental transfer, cytotoxicity, and teratology in the rat
Am J Obstet Gynecol
(1981) - et al.
Indomethacin: studies of absorption and placental transfer
Am J Obstet Gynecol
(1977) - et al.
Pharmacokinetics of intravenously administered indomethacin in premature infants
J Pediatr
(1980) - et al.
Further study of the inhibition of premature labor by indomethacin. Part II double blind study
J Perinat Med
(1984) Prostaglandin synthetase inhibitors
Semin Perinatol
(1981)
Cited by (95)
Pharmacokinetics in pregnancy
2022, Reproductive and Developmental ToxicologyTargeted drug delivery for maternal and perinatal health: Challenges and opportunities
2021, Advanced Drug Delivery ReviewsAntenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin
2021, Journal of PediatricsCitation Excerpt :Associations between postnatal prophylactic indomethacin and SIP remain controversial.20-22 There is biologic plausibility for antenatal indomethacin as a risk factor for postnatal SIP reflecting ready passage across the placenta23 and reductions in regional blood flow to the intestine, kidneys, and cerebrum.24,25 There are limited data on associations of antenatal indomethacin exposure with SIP because the latter was not analyzed in meta-analyses.26,27
Preventing preterm birth: New approaches to labour therapeutics using Nanoparticles
2018, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :This is because most therapeutics lack specificity and being small molecules they can cross the placenta to enter the foetus, where they can affect foetal development [12]. A prominent example is indomethacin, which upon crossing the placenta and entering the foetus [23] can cause necrotising enterocolitis [24] and intraventricular haemorrhage [25] and affect closure of the ductus arteriosus [26–28]. Despite prostaglandin synthesis inhibitors, such as indomethacin, having one of the highest probabilities of delaying labour and improving neonatal and maternal outcomes [2], the associated side effects are sufficient to negate their use.
Targeted nanoparticles in pregnancy: a new frontier in perinatal therapeutics
2017, American Journal of Obstetrics and Gynecology