The use of histidase for the study of amniotic cell origin and histidinemia

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Abstract

Histidase activtiy in the human fetal epidermis and amniotic cells was studied to establish an epidermal origin of amniotic cells. Whereas fetal skin contains histidase activity as early as 20 weeks' gestation, in amniotic cells histidase activity appeared only at term and, even then, there was a wide variability in specific activity levels. Significance of these results to amniotic cell origins and to the use of amniotic cells in prenatal diagnosis of histidinemia is discussed.

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Cited by (3)

Supported by funds from Developmental Biology Training Grant T01-HD00297 and Research Grant HD01253, National Institutes of Health (to Dr. A. A. Moscona).

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