Clinical studiesHuman immunodeficiency virus-associated meningitis: Clinical course and correlations☆
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Cited by (104)
Aseptic and Viral Meningitis
2017, Principles and Practice of Pediatric Infectious DiseasesThe UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults
2016, Journal of InfectionCitation Excerpt :Up to 24% of patients with acute HIV infection may present with meningitis as part of a seroconversion illness.218–220 Headache and fever are common and there are often also other symptoms or signs such as lymphadenopathy, oral candidiasis or rash.215,221 The prevalence of HIV in culture negative meningitis has been reported between 1 and 5% in German and US cohorts.19,222
Viral diseases of the central nervous system
2015, Current Opinion in VirologyCitation Excerpt :The vast majority of aseptic meningitis cases are caused by human enteroviruses (HEV) [27,28] that mostly target children [29,30]. However, many other viruses have the ability to cause meningitis including St. Louis encephalitis virus (SLEV) [31], bunyaviruses [32–34], mumps virus [35], lymphocytic choriomeningitis virus (LCMV) [36], HSV-1 and 2 [37,38], and human immunodeficiency virus (HIV)-1 [39]. Because most adult infections resolve without long term sequelae, pathological data are scarce.
Acute Meningitis
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesClinical approach to the syndromes of viral encephalitis, myelitis, and meningitis
2014, Handbook of Clinical NeurologyCitation Excerpt :Some patients may develop vasculopathy or myelitis, particularly immunocompromised patients. HIV is a well-recognized cause of aseptic meningitis and may occur in up to 10% of patients during seroconversion (Hollander and Stringari, 1987; Atwood et al., 1993). HIV enters the CNS early in infection (as early as 8 days) and often remains detectable later in infection (Spudich et al., 2011; Valcour et al., 2012).
Adaptive immune response to viral infections in the central nervous system
2014, Handbook of Clinical NeurologyCitation Excerpt :The characteristic neurocognitive disorder during this acute infection is a meningoencephalitis that is self-limiting through the actions of the innate and adaptive immune responses, resulting in the clearance of HIV-1-infected macrophages/microglia by HIV-1-specific CTLs (Poluektova et al., 2004). This acute meningitis occurs at the time of seroconversion in relatively immunocompetent individuals (Hollander and Stringari, 1987). CSF pleocytosis accompanies this early neurocognitive disorder (McArthur et al., 1989) or may be present in asymptomatic HIV-1-infected individuals (Spudich et al., 2005; Marra et al., 2007).
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This work was supported by grants from the University of California Systemwide Taskforce on AIDS and was presented in part at the Third International Conference on AIDS in Washington, D.C., June 1987.