Clinical study
Anti-lymphocyte antibodies in patients with the acquired immune deficiency syndrome

https://doi.org/10.1016/0002-9343(85)90405-XGet rights and content

Abstract

Human lymphotropic retroviruses lymphadenopathy-associated virus/human T lymphoma virus III have been recently implicated In the pathogenesis of the acquired immune deficiency syndrome (AIDS). The mechanisms leading to the complex immune deregulations of this disease, however, are still largely unknown. To investigate the possible presence of anti-lymphocyte antibodies, lymphocytes from a normal donor were incubated with serum samples from patients with AIDS. Substantial increases of up to 75 percent in the number of surface immunoglobulin-positive lymphocytes resulted from incubation with serum of patients with AIDS and AIDS-related complex but not with serum of patients with non-AIDS-related diseases or of normal control subjects. Monoclonal antibodies to OKT11, OKT4, and OKT8 in conjunction with a double-labeling technique were then used to identify the type of surface immunoglobulin-positive lymphocytes. These experiments showed that binding of immunoglobulins to lymphocytes did not occur at random but was directed against OKT4- or OKT11-positive cells whereas OKT8-positive cells showed no detectable reactivity. The results of these studies indicate that patients with AIDS and AIDS-related complex have circulating antibodies capable of reacting selectively with a population of T cells that is predominantly composed of helper cells and does not include suppressor cells. The augmentation of surface immunoglobulin-positive lymphocytes in the patients studied consistently paralleled the marked decreases of the helper/suppressor cell ratios and the presence of circulating anti-human T lymphoma virus III antibodies. Binding of antibodies to the surface of helper T cells may be a determining event in the pathogenesis of this disease.

References (19)

  • WL Drew et al.

    Cytomegalovirus and Kaposi's sarcoma in young homosexual men

    Lancet

    (1982)
  • MI McDonald et al.

    Hepatitis B surface antigen could harbour the infective agent of AIDS

    Lancet

    (1983)
  • Centers for Disease Control

    Kaposi's sarcoma and pneumocystis pneumonia among homosexual men-New York City and California

    Morbid Mortal Weekly Rep

    (1981)
  • Centers for Disease Control

    Epidemiologic aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections

    N Engl J Med

    (1982)
  • HL loachim

    Acquired immune deficiency disease after three years, the unsolved riddle (editorial)

    Lab Invest

    (1984)
  • Centers for Disease Control

    Persistent, generalized lymphadenopathy among homosexual males

    Morbid Mortal Weekly Rep

    (1982)
  • HL loachim et al.

    Lymphadenopathies in homosexual men: relationships with the acquired immune deficiency syndrome

    JAMA

    (1983)
  • HL loachim et al.

    The lymphoid lesions associated with the acquired immunodeficiency syndrome

    Am J Surg Pathol

    (1983)
  • J Sonnabend et al.

    Acquired immunodeficiency syndrome, opportunistic infections and malignancies in male homosexuals

    JAMA

    (1983)
There are more references available in the full text version of this article.

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