Symposium on diabetes mellitus (Part III)Insulin secretion in diabetes mellitus☆
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Cited by (317)
Recent Developments in Islet Biology: A Review With Patient Perspectives
2023, Canadian Journal of DiabetesCitation Excerpt :Insulin is released from pancreatic ß cells after a meal, stimulated by glucose and other secretagogues, including fatty acids and amino acids (1,2). Appropriate insulin secretion in response to a rise in plasma glucose is essential for maintaining normoglycemia (3). After the entry of glucose into ß cells, glucose is oxidized initially in glycolysis, which is initiated by phosphorylation of glucose by glucokinase (GCK).
Insulin therapy; a valuable legacy and its future perspective
2021, International Journal of Biological MacromoleculesA direct look at the dysfunction and pathology of the β cells in human type 2 diabetes
2020, Seminars in Cell and Developmental BiologyCitation Excerpt :Type 2 diabetic subjects have blood insulin levels that are inappropriately low for the prevailing glucose concentrations [6,11,21,52]. Abnormalities of the temporal pattern of insulin secretion in this form of diabetes have been shown as well, that include loss or blunted first phase release in response to intravenous glucose and alterations of pulsatility cycles [6,11,21,52]. Some of these features have been investigated also ex vivo with islets isolated from type 2 diabetic donors [40,41,44,53–56].
Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas
2019, Developmental CellCitation Excerpt :The picture of two functionally distinct pools of beta cells could also account for islet malfunction in insulin-resistant states. A hallmark of insulin resistance, which is observed also in db/db mice, is the lack of first-phase insulin secretion (Pfeifer et al., 1981; Unger and Orci, 2010). In healthy states, insulin is released in a biphasic manner due to a rapid and sustained increase of glucose following a meal.
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This investigation was supported in part by a Public Health Service Special Emphasis Research Career Award (AM 00738) from the National Heart, Lung, and Blood Institute; by Grants AM 17047, AM 12829 and AM 20754 from the National Institutes of Arthritis, Metabolism, and Digestive Diseases, and by the Veterans Administration. It was presented at a Symposium on Diabetes Management sponsored by the Upjohn Company, held in Miami, Florida, February 29–March 1, 1980.
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From the Division of Endocrinology and Metabolism, Department of Medicine, University of Washington School of Medicine, and the Geriatric Research, Education, and Clinical Center of the Veterans Administration Medical Center, Seattle, Washington.