Arrhythmias and conduction disturbanceLong-term recording of monophasic action potentials from human endocardium
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Cited by (184)
Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: Historical perspectives, current progress and future prospects
2014, Progress in Biophysics and Molecular BiologyCitation Excerpt :Early MAP recordings during cardiac catheterisation procedures were made with a catheter that employed suction onto the endocardium (Olsson et al., 1971). Subsequently most MAP recordings have been obtained using the Franz contact electrode concept in a bipolar configuration (Franz, 1983, 1991; Franz et al., 1986; Moore and Franz, 2007). One Ag–AgCl electrode is in contact with myocardium which is partially depolarised as a result of the pressure contact and a second Ag–AgCl electrode is in contact with the adjacent non depolarised tissue (see Fig. 1).
Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs
2011, Journal of Molecular and Cellular CardiologyCitation Excerpt :Surface ECG, heart rate, and arterial blood pressure were continuously monitored by a polygraph recording system (LEG1000, Nihon-Kohden, Tokyo, Japan). We inserted a 7-Fr sheath into the left carotid artery for cardiac catheterization and a 9-Fr sheath into the right carotid artery for evaluation of monophasic action potential (MAP), which is a useful marker of cardiac electrical stability [15]. Then, myocardial ischemia in the territory of the left circumflex coronary artery (LCx) was induced by inflated a coronary angioplasty balloon catheter with a lowest pressure that completely occluded distal coronary flow.
Electrophysiologic characteristics of an Andersen syndrome patient with KCNJ2 mutation
2007, Heart RhythmCitation Excerpt :Clinical studies using MAP recording have suggested that early afterdepolarizations play an important role in the genesis of QT prolongation and ventricular arrhythmias in LQTS. Catecholamine and sympathetic stimulation exaggerate early afterdepolarizations and QT prolongation and subsequently cause ventricular arrhythmias in LQTS.12–16 In this study, we observed DAD-like humps in a patient with Andersen syndrome and the KCNJ2 mutation T192A.
Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: Experimental evidence to resolve some controversies
2006, Heart RhythmCitation Excerpt :Because KCl injection is not feasible in studies on humans, other means of depolarization have been used. Pressure applied by the tip of a Franz electrode has the same effect, as does suction applied on tissue surrounding the exploring electrode.5,6 Figure 3 has demonstrated how the local T wave interferes with the end of the monophasic potential.
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Dr. Franz is a recipient of a research fellowship grant from the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, German Federal Republic.