Inotropic responsiveness of the heart in catecholamine cardiomyopathy☆
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Pharmacological assessment of zebrafish-based cardiotoxicity models
2022, Biomedicine and PharmacotherapyInsulin and short acting iv beta blockers: A “new” proposal for the acute management of takotsubo syndrome
2021, International Journal of CardiologyCongestive heart failure and upper extremity deep vein thrombosis: A rare presentation of a pheochromocytoma
2020, Journal of Taibah University Medical SciencesCitation Excerpt :Left ventricular hypertrophy and hypertensive cardiomyopathy may occur in patients with chronic hypertension from pheochromocytoma. In addition, the long-term elevation of catecholamine levels leads to significant desensitisation of beta-adrenergic receptors.10 Oxidised catecholamines may increase the permeability of the sarcolemmal membrane, leading to calcium influx and intracellular calcium overload, which may can result in acute myocarditis, with diffuse interstitial inflammatory infiltrates and myocardial necrosis.9
Adrenergic cardiomyopathy and cardiogenic shock as initial presentation of pheochromocytoma. A case report and review of the literature
2018, International Journal of Surgery Case ReportsPrevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease
2013, Journal of the American College of CardiologyCitation Excerpt :The features of mental stress–induced and exercise stress–induced segmental abnormal wall motion changes are particularly interesting in consideration of the Takotsubo, or stress-induced cardiomyopathy (also known as apical ballooning syndrome) (35–37). The stress-induced greater increase of WMA in the mid- and apical segments than in the basal segments of the left ventricle may reflect a combination of myocardial necrosis and regionally decreased beta-adrenoceptor responsiveness with high local catecholamine concentrations, that is, “neurogenic stunned myocardium” that was suggested by findings from animal studies (39,40). However, our study was not designed to evaluate whether the experimental mental and physical stress tests produce Takotsubo cardiomyopathy–like manifestations, and further discussion of its relevance to the present study would be highly speculative.
Cardiovascular dysfunction and catecholamine cardiomyopathy in pheochromocytoma patients and their reversal following surgical cure: Results of a prospective case-control study
2011, SurgeryCitation Excerpt :Such polymorphisms enhance the susceptibility to develop cardiomyopathy either by increasing the sensitivity to catecholamines or increasing synaptic norepinephrine levels through loss of negative feedback.20 The genesis of cardiomyopathy in PCC is multifactorial, and causes include chronic tachycardiomyopathy secondary to a hyperadrenergic state,21 vasoconstriction and coronary vasospasm or direct receptor-mediated effects of catecholamines on the myocardium and downregulation of β-adrenergic receptors.22 The increased catecholamines also enhance cell membrane peroxidative and lipoperoxidative metabolism, enhanced generation of free radicals, and subsequent myocardial injury.
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Supported by research grant HL-20401, and in part by grant HL-08659 and by training grant HL-07272 from the National Institutes of Health.