TEACHING CASEAbout a case of GIST occurring during pregnancy with immunohistochemical expression of epidermal growth factor receptor and progesterone receptor
Introduction
Gastric cancer developing during pregnancy is very rare, with only 92 cases reported over the last 30 years [7]. The coexistence of gastrointestinal stromal tumors (GISTs) and pregnancy is also very rare, with only one case reported in the literature [19].
We present a case of GIST occurring during pregnancy with immunohistochemical staining for epidermal growth factor receptor (EGFR) and progesterone receptor (PgR).
Section snippets
Case report
A 29-year-old female, in the 22nd week of gestation, presented with complaints of abdominal pain. Her past medical history was negative for any disease. She denied sickness, emesis, constipation, or vaginal bleeding. Physical and obstetrical examinations were normal except for the presence of abdominal fluid. Laboratory evaluation demonstrated hemoglobin of 9.2 g/dl. An echographic examination demonstrated intrauterine fetus without anomalies and a large amount of abdominal fluid (Fig. 1). Fluid
Discussion
The literature contains only few reports of gastric tumors occurring during pregnancy, the majority of them being adenocarcinomas [9], [13]. It is very rare that GISTs develop during pregnancy.
Usually, GISTs are detected in adults over 30 years of age, affecting men and women equally. GISTs may appear singly or in clusters, and their size may vary from small intramural lesions to bulky tumor masses. In general, small tumors of the stomach are asymptomatic, benign intramural lesions; large
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Cited by (23)
Niclosamide nanocrystal for enhanced in-vivo efficacy against gastrointestinal stromal tumor via regulating EGFR/STAT-3/DR-4 axis
2023, Journal of Drug Delivery Science and TechnologyA rare maternal gastrointestinal stromal tumor found in the second trimester of pregnancy: A case report
2020, Case Reports in Women's HealthCitation Excerpt :The tumors very rarely present during pregnancy. We found ten reported cases of GIST in pregnancy (Table 1) [3–12]. Their average time at diagnosis was 18 weeks of gestation (13–28 weeks).
Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature
2016, Journal of Advanced ResearchCitation Excerpt :Imatinib treatment during pregnancy or breast feeding is contra-indicated since spontaneous miscarriages and birth defects have been reported. Prognosis of women with gestational GIST remains favorable [57–65]. Gestational synovial sarcomas are rare sarcomas.
An elective combined caesarean section and small bowel GIST resection during the third trimester of pregnancy: Report of a case
2013, International Journal of Surgery Case ReportsCitation Excerpt :Rarely, patients may present acutely due to either an obstruction or a perforation of a viscus.14 Constitutional symptoms are not uncommon in pregnancy and thus the presentation of GISTs in pregnancy can pose a diagnostic challenge.8 Attaining a diagnosis in pregnancy is difficult, as it is normally recommended that computed tomography is undertaken to accurately stage the tumour.11,15
HER-2 status in gastrointestinal stromal tumor
2008, Annals of Diagnostic PathologyCitation Excerpt :The KIT and PDGFRA genes encode for similarly named receptor tyrosine kinase proteins that are involved in intracellular signaling pathways that control cell survival [9,10], and the KIT/PDGFRA tyrosine kinase inhibitor imatinib mesylate (Gleevec; Novartis Pharma, Basel, Switzerland) has been used for the treatment of GIST by reducing receptor tyrosine kinase activity [11]. The role of other growth factor receptors has been investigated in GIST, including the EGFR [12-16]. However, only 2 studies [12,13] were published so far regarding HER-2 and GIST.