Original ArticleThe Rate of Bloodstream Infection Is High in Infants with Short Bowel Syndrome: Relationship with Small Bowel Bacterial Overgrowth, Enteral Feeding, and Inflammatory and Immune Responses
Section snippets
Methods
Children younger than 2 years of age with a history of SBS caused by massive small bowel or colonic resection or both after the diagnosis of NEC were enrolled in this study. SBS was defined as dependence on PN for at least 3 months with bowel length (measured along the antimesenteric border from the ligament of Treitz) of less than 30% of estimated normal small bowel length for age.15, 16 Normal small bowel length for age was estimated by use of previously published data.16 The children with
Discussion
The treatment of children with SBS is complex and expensive.4 Duration of PN and recurrent BSI are among the predictors of survival and overall outcomes previously identified.4, 6, 24 Limited data in children with SBS suggest a high risk for development of SBBO.7, 25 Our study provides novel information regarding an apparent increased risk for BSI in children with SBS and SBBO and the relationship between the route of nutrition and serum proinflammatory cytokine levels.
Although our data are
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2022, GastroenterologyCitation Excerpt :CMC consumption was not associated with severe adverse events or alterations in serum levels of inflammatory cytokines, nor did it have an appreciable impact on appetite, food consumption, or bloating (Figure 1E and Supplementary Figure 2). Moreover, levels of anti-lipopolysaccharide and anti-flagellin immunoglobulin G antibodies, which have been used as an indirect measure of gut permeability,23,24 did not change over the course of the study in control or CMC-fed subjects (Supplementary Figure 3). CMC consumption did associate with a modestly significant increase in postprandial abdominal pain (Figure 1F, P = .019).
Supported in part by National Institutes of Health grants K12 RR017643 and KL2 RR025009 (to CRC), R01 DK55850 and K24 RR023356 (to T.Z.), UL1 RR025008 from the Clinical and Translational Science Award program and M01 RR0039 from the General Clinical Research Center program, National Center for Research Resources. The authors declare no conflicts of interest.