Reproductive endocrinologyEarly metformin therapy to delay menarche and augment height in girls with precocious pubarche
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Key Words
Metformin
menarche
insulin
IGF-I
DHEAS
puberty
pubarche
birthweight
epigenetic
androgen excess
polycystic ovary syndrome
PCOS
obesity
height
adrenarche
lipids
abdominal fat
subcutaneous fat
adiposity
hepatic fat
fatty liver
visceral fat
body composition
lean mass
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L.I., M.D., and M.V.M. are Clinical Investigators of CIBERDEM, Madrid, Spain). A.L-B. is an Investigator of the Fund for Scientific Research I3 (Ministry of Education and Science, Spain). F.d.Z. is an Investigator of the Clinical Research Council of the University Hospital Leuven.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.