Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)
Graphical abstract
Substituted benzoxazol-2-ones are reported as antagonists of the signaling by macrophage migration inhibitory factor (MIF). One of the potent analogues is shown to attenuate MIF-dependent ERK1/2 phosphorylation in human synovial fibroblasts.
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Acknowledgments
Gratitude is expressed to T. Lam and E. Voss of the Keck Biotechnology Facility and the National Institutes of Health (AIO42310, AR049610, AR050498, GM032136) for support.
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