Original articleCardiovascularStable Cognition After Coronary Artery Bypass Grafting: Comparisons With Percutaneous Intervention and Normal Controls
Section snippets
Enrollment
Institutional review board approval was obtained in February 2002, and fully informed written consent was obtained from individuals selected for participation in this study. Prospective participants in the two cardiac groups (CABG or PCI) were screened by project personnel subsequent to physician referral based on standard clinical indications for either CABG or PCI. Exclusion criteria for cardiac patients included those reflecting excessive risk of neurologic events, or potential inability to
Intergroup Conformity
The three cohorts were well matched for age, and each group was relatively well educated, with well over half of each group having a college degree or advanced degree (Table 2). There were more men than women in the CABG and PCI groups, with the control group being equally divided, reflective of the distribution of sex in these populations. Patterns of comorbidities in the CABG and PCI subjects were consistent with the degree of atherosclerotic disease in these groups and the relatively limited
Comment
The present study demonstrates that the majority of neurocognitive functions measured as early as 3 weeks postoperatively are essentially unchanged compared with baseline in individuals undergoing CABG surgery. These findings are consistent with the recent review of Selnes and McKhann [7], who concluded that in current studies neurocognitive complications of CABG were mild.
Within the present study, results varied considerably depending on which of four analytic methods were used to determine
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2011, American Heart JournalCitation Excerpt :Overall, the presence of microlesions was associated with a decline in cognitive tests. In the pertinent literature, a small variety of studies used patients who underwent cardiac catheterization as a control group for CABG.4-7,14,15 Interestingly, nearly all of these studies failed to attest postoperative cognitive decline in the CABG group in comparison with a PCI group.