Family history of autoimmune diseases in psychosis
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2015, Brain ResearchCitation Excerpt :In a population-based study using personal and family data from 7704 Danish psychiatric patients with schizophrenia, a personal history of auto-immune disease in patients or their family members was associated with a 45% increased risk for schizophrenia, and schizophrenia in turn was associated with a 50% elevated prevalence of autoimmune diseases compared with the general population (Eaton et al., 2006), a finding that has been replicated in recent, larger studies (Benros et al., 2011, 2014b; Eaton et al., 2010). In addition, elevated rates of numerous auto-immune disorders have been found among the relatives of patients with schizophrenia, with especially high rates for type 1 diabetes and thyrotoxicosis (Eaton et al., 2006; Gilvarry et al., 1996; Wright et al., 1996). Considerable evidence exists for the heritability of both schizophrenia and many autoimmune diseases (Cho and Gregersen, 2011; Sullivan et al., 2003); interestingly, data from recent genome-wide studies have associated both schizophrenia and autoimmune diseases with a gene family, the major histocompatibility complex (MHC), that is crucially involved in immune function and autoimmunity.