The microtubule cytoskeleton and the development of neuronal polarity
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Cited by (57)
To target Tau pathologies, we must embrace and reconstruct their complexities
2021, Neurobiology of DiseaseCitation Excerpt :In neuronal cells, under normal conditions, Tau is predominantly localized to axonal compartment (Kosik and Finch, 1987) and is involved in axonal (Zempel and Mandelkow, 2019) and synaptic functions (Hoover et al., 2010; Decker and Mandelkow, 2019) as well as in neurovascular coupling processes (Park et al., 2020). By virtue of its microtubule (MT)-binding profile, Tau was found to carry out important roles in cytoskeletal maintenance (Mandell and Banker, 1995), mitochondrial transport (Shahpasand et al., 2012), trafficking of cargo along MTs (Chaudhary et al., 2018), cell signalling (Li et al., 2018), and maintenance of chromatin organization (Villasante et al., 1981; Galas et al., 2019). Tau is also involved in many cellular processes and pathways, such as stress responses (Maina et al., 2018) and cell proliferation (Yi et al., 2019).
Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease
2014, Trends in NeurosciencesCitation Excerpt :Although most protein synthesis in mature mammalian neurons occurs in the soma, the axon represents up to 99% of the volume of a cell, requiring efficient transport. The process of neuritic outgrowth and cell differentiation can be subdivided into five ‘Banker’ stages [16,30]: (i) formation of lamellipodia; (ii) outgrowth of minor processes; (iii) formation and growth of the axon; (iv) growth of the dendrites; and (iv) maturation. With increasing maturation, Tau becomes sorted into axons (in contrast to MAP2 which is restricted to soma and dendrites).
Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons
2014, NeuroToxicologyCitation Excerpt :Moreover, we found neurites with strong Tau and weak MAP2 signals in ESCN. In mature neurons MAP2 is absent in axons and located only somato-dendritically, whereas Tau is mainly present in axons (Bernhardt and Matus, 1984; Binder et al., 1985; Dotti et al., 1987; Kosik and Finch, 1987; Mandell and Banker, 1995). In the developing neuron, Tau segregates into axons and MAP2 into dendrites right after axogenesis (Matus, 1990).
The Cytoskeleton of Neurons and Glia
2012, Basic NeurochemistryThe Cytoskeleton of Neurons and Glia
2011, Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology: Eighth EditionThe development of neuronal morphology in insects
2005, Current BiologyCitation Excerpt :Neurons develop intricate and astoundingly diverse branching morphologies. In both vertebrate and invertebrate neurons, axons appear to emerge first from the cell body, followed by the growth of dendrites [8,31,32]. A major difference in morphology between invertebrate and vertebrate neurons is that the majority of vertebrate neurons is multipolar while the majority of invertebrate neurons is unipolar [33,34].