From the Society for Developmental BiologyDiscoidin domain receptors guide axons along longitudinal tracts in C. elegans
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Highlights
► We characterize the role of discoidin domain receptors during neural development. ► ddr-2 mutants exhibit guidance defects in longitudinal axon tracts of C. elegans. ► ddr-1 mutants show no phenotype on their own but act synergistically with ddr-2. ► ddr-1 and ddr-2 are expressed in all affected axon tracts and localize to axons. ► DDR-2 is required cell-autonomously in the ventral nerve cord pioneer neuron PVPR.
Keywords
Neuronal development
Nervous system
Neuron
PVP
Pioneer
Axon guidance
Axon navigation
Discoidin domain receptors
Receptor tyrosine kinase
DDR-1
DDR-2
Ventral nerve cord
Dorsal nerve cord
C. elegans
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