Trends in Neurosciences
ReviewAir pollution: mechanisms of neuroinflammation and CNS disease
Section snippets
Air pollution defined
Air pollution is comprised of a diverse mixture of particulate matter (PM), gases (e.g. ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides), organic compounds (e.g. polycyclic aromatic hydrocarbons and endotoxins) and metals (e.g. vanadium, nickel, and manganese) present in outdoor and indoor air [5]. Of these components, PM and ground-level ozone are the most widespread health threats and have been heavily implicated in disease 2, 4. In fact, millions of people in the USA and
Ischemic stroke
While it is well-known that air pollution affects human health through cardiovascular and respiratory morbidity and mortality, it has only recently been shown that these deleterious effects extend to the brain. The impact of air pollution upon the brain was first noted as an increase in ischemic stroke in individuals exposed to indoor coal fumes [16]. In the United States, stroke is the number one cause of adult disability and the third most common cause of death, behind only cancer and heart
Route of CNS effects
Recent advances have provided key insights into how air pollution exerts deleterious effects on the brain. Specifically, cerebral vascular damage, neuroinflammation, and neurodegeneration in response to air pollution are believed to occur through four major pathways (Figure 1).
Cellular mechanisms of neuroinflammation
In addition to understanding how the effects of air pollution reach the brain, recent studies have begun to address the cell types that mediate air pollution-induced CNS pathology.
Summary and conclusions
In summary, air pollution is a complex mixture of environmental toxicants that assault the CNS through several cellular and molecular pathways to cause disease. CNS effects are chronic, beginning in childhood, and may take time (years) to accumulate pathology. Specifically, air pollution causes neuroinflammation, oxidative stress, cerebrovascular damage, and neurodegenerative pathology. The effects of air pollution cross from the periphery to the brain through systemic inflammation and
Acknowledgements
This work was supported by the NIEHS/NIH Pathway to Independence Award R00ES01549.
References (105)
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Nat. Rev. Neurosci.
(2007)Air pollution and public health: a guidance document for risk managers
J. Toxicol. Environ. Health A
(2008)The effect of air pollution on asthma and allergy
Curr. Allergy Asthma Rep.
(2008)Adverse cardiovascular effects of air pollution
Nat. Clin. Pract. Cardiovasc. Med.
(2009)Global air quality and pollution
Science
(2003)Interactions of nanoparticles with pulmonary structures and cellular responses
Am. J. Physiol. Lung Cell. Mol. Physiol.
(2008)Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms
J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.
(2008)A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles
ALTEX
(2008)Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms
J. Am. Coll. Cardiol.
(2008)Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression
Environ. Res.
(2007)
Air pollution and brain damage
Toxicol. Pathol.
DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration
Toxicol. Pathol.
Translocation and potential neurological effects of fine and ultrafine particles a critical update
Part. Fibre Toxicol.
Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution
Toxicol. Pathol.
Translocation of inhaled ultrafine particles to the brain
Inhal. Toxicol.
Indoor air pollution of coal fumes as a risk factor of stroke
Shanghai. Am. J. Public. Health.
Heart disease and stroke statistics – 2009 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Circulation
Air pollution and risk of stroke: underestimation of effect due to misclassification of time of event onset
Epidemiology
Ambient air pollution and risk for ischemic stroke and transient ischemic attack
Ann. Neurol.
Air pollution: a new risk factor in ischemic stroke mortality
Stroke
Associations of fine and ultrafine particulate air pollution with stroke mortality in an area of low air pollution levels
Stroke
Lung toxicity of ambient particulate matter from southeastern U
S. sites with different contributing sources: relationships between composition and effects. Environ. Health Perspect.
How common are the “common” neurologic disorders?
Neurology
An estimate of the worldwide prevalence and direct costs of dementia in 2003
Dement. Geriatr. Cogn. Disord.
Parkinson's disease
Hum. Mol. Genet.
The olfactory vector hypothesis of neurodegenerative disease: is it viable?
Ann. Neurol.
Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults
Toxicol. Pathol.
Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs
Brain Cogn.
Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain
Neurotoxicology
Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways
Toxicol. Lett.
Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease
Environ. Health Perspect.
Chronic nasal instillation of residual-oil fly ash (ROFA) induces brain lipid peroxidation and behavioral changes in rats
Inhal. Toxicol.
Nanoparticles as catalysts for protein fibrillation
Proc. Natl. Acad. Sci. U. S. A.
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
Proc. Natl. Acad. Sci. U. S. A.
The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century
Adv. Colloid Interface Sci.
Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product
J. Mol. Biol.
Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation
J. Biol. Chem.
Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis
Cell Transplant.
Parental smoking at home and the risk of childhood-onset multiple sclerosis in children
Brain
A study of the relationships between Parkinson's disease and markers of traffic-derived environmental maganese air pollution in two Canadian cities
Environ. Res.
Effects of subchronic exposures to concentrated ambient particles. VII. Degeneration of dopaminergic neurons in Apo E-/- mice
Inhal. Toxicol
Systemic infection, inflammation and acute ischemic stroke
Neuroscience
Inflammation markers and prediction of post-stroke vascular disease recurrence: the MITICO study
J. Neurol.
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
Biol. Psychiatry
Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation
J. Neurosci.
From inflammation to sickness and depression: when the immune system subjugates the brain
Nat. Rev. Neurosci.
Reflex control of immunity
Nat. Rev. Immunol.
Impaired lung function and risk for stroke: role of the systemic inflammation response?
Chest
Oxidatively damaged DNA and inflammation in the liver of dyslipidemic ApoE-/- mice exposed to diesel exhaust particles
Toxicology
Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters
Eur. Respir. J.
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