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Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

https://doi.org/10.1016/j.tibs.2015.07.007Get rights and content
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G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.

Keywords

GPCR
model
structure
dimers
heteromer
oligomer

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