Trends in Endocrinology & Metabolism
Research FocusDoes bone resorption inhibition affect the anabolic response to parathyroid hormone?
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Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells
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Cited by (36)
Introducing a new method for evaluation of the interaction between an antigen and an antibody: Single frequency impedance analysis for biosensing systems
2014, TalantaCitation Excerpt :Parathyroid hormone (PTH) is secreted from cells of parathyroid glands and has a vital role in the regulation of calcium and phosphorous concentration in extracellular fluid [1–3].
Parathyroid Hormone and Parathyroid Hormone-Related Protein
2013, Osteoporosis: Fourth EditionBone remodelling: its local regulation and the emergence of bone fragility
2008, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :The anabolic effect of PTH is lost in c-fos−/− mice that are osteopetrotic because of failure of osteoclast formation.57 Treatment of patients with osteoporosis with PTH and an anti-resorptive agent blunts the response to PTH58,59, implying that combining the anabolic PTH with anti-resorptive bisphosphonate would be associated with a less effective anabolic effect.60,61 Treatment of rats with a single subcutaneous injection of PTH results in a transient increase in mRNA for RANKL and a decrease in that for OPG, with maximum effect at 1 hour, and returning to control within 2 hours, consistent with a subtle or transient activation of the osteoclast that might be needed to prepare the bone surface for new matrix deposition.62
Parathyroid Hormone and Parathyroid Hormone-Related Protein
2008, Osteoporosis, Two-Volume SetCREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment
2007, BoneCitation Excerpt :Our data indicate that CREM deficiency does not affect the increase in osteoblast surface and the bone formation rate seen in response to intermittent PTH, suggesting either that CREM is not involved in this response or that other ATF/CREB factors may have compensated for CREM. It has been suggested that the anabolic effect of PTH is mediated through effects on bone remodeling [29]. In WT mice, the effect on bone formation outweighed bone resorption, leading to an increase in bone mass.
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
2006, Cell MetabolismCitation Excerpt :Mechanical forces and certain systemic factors, such as steroids or parathyroid hormone, affect bone remodeling. For the anabolic effect of parathyroid hormone to occur, bone resorption may be necessary, implying that osteoblast formation requires signals from osteoclasts (Martin, 2004). Local factors including TRAP secreted by osteoclasts (Sheu et al., 2003) and insulin-like growth factor and transforming growth factor-β, which are released from bone matrix during bone resorption (Hayden et al., 1995; Pfeilschifter and Mundy, 1987), can stimulate bone formation.