Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation
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Graphical abstract
Abbreviations
ADP
adenine dinucleotide phosphate
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
CPT1
carnitine palmitoyl transferase 1
DMEM
Delbucco's Eagle Modified Medium
Drp1
dynamin-related protein 1
EDTA
ethylenediaminetetraacetic acid
EGTA
ethylene glycol tetraacetic acid
MOPS
3-(N-morpholino)propanesulfonic acid
Fis1
mitochondrial fission 1 protein
FCCP
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
FBS
fetal bovine serum
HEPES
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
NDUFB8
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8
NP-40
noniodet P40
LC3
(microtubule-associated protein 1 light chain 3)
Opa1
optic atrophy 1
PCNA
proliferating cell nuclear antigen
PDGF-BB
platelet-derived growth factor-BB
PVDF
polyvinylidene fluoride
SDS
sodium dodecyl sulfate
SDHB
succinate dehydrogenase subunit B
TMPD
N,N,N′,N′-tetramethyl-p-phenylenediamine
VSMC
vascular smooth muscle cells
Keywords
Metabolism
Oxidative phosphorylation
Restenosis
Atherosclerosis
Fusion
Extracellular flux
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Copyright © 2013 The Authors. Published by Elsevier B.V.