The GABA type A receptor α5 subunit gene is associated with bipolar I disorder

doi:10.1016/j.neulet.2005.02.010

Neuroscience Letters

Volume 381, Issues 1–2, 10–17 June 2005, Pages 108-113

https://doi.org/10.1016/j.neulet.2005.02.010 Get rights and content

Abstract

Several genetic studies have revealed that bipolar disorders are linked with the chromosomal locus of 15q11–q13, where the γ-aminobutyric acid (GABA) receptor α5 subunit gene (GABRA5) locates. GABA is one of the major neurotransmitters that may be involved in the pathogenesis of bipolar disorder. Five polymorphisms in the GABRA5 gene, −754C > T in the promoter region, IVS1-21G > A, IVS2-26T > A, ^*302C > T in 3′-UTR of exon 5, and a CA repeat polymorphism in the 3′ flanking region were examined in a Japanese population. IVS1-21G > A exhibited significant differences in the distribution of the genotype and allele frequency in bipolar I disorder patients but not in bipolar II disorder patients, compared with control subjects. The haplotype analysis showed that IVS1-21G > A/IVS2-26A > T was associated with bipolar I disorder, and the IVS1-21A/IVS2-26T haplotype was a negative risk factor for susceptibility to the disorders (odds ratio: 0.57, 95% confidence interval: 0.44–0.73). These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder.

Section snippets

Acknowledgments

This work was partly supported by the Zikei Institute of Psychiatry (Okayama, Japan). We wish to thank the participants for assisting in the collection of blood samples and clinical information.

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View full text

The GABA type A receptor α5 subunit gene is associated with bipolar I disorder

Abstract

Section snippets

Acknowledgments

Reduced plasma and CSF gamma-aminobutyric acid in affective illness: effect of lithium carbonate

Biol. Psychiatry

Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder

Arch. Gen. Psychiatry

GABAergic dysfunction in mood disorders

Mol. Psychiatry

GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs

Neuropharmacology

The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia

Biol. Psychiatry

A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission

Psychiatr. Genet.

Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder

J. Psychiatry Neurosci.

Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia

Arch. Gen. Psychiatry

Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders

Biol. Psychiatry

The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions

EMBO J.

The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials

Pharmacol. Biochem. Behav.

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock

J. Pharmacol. Exp. Ther.

Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study

Mol. Psychiatry

Population and family studies in depression and mania

Br. J. Psychiatry Suppl.