Clinical studyLeiomyoma Infarction after Uterine Artery Embolization: A Prospective Randomized Study Comparing Tris-acryl Gelatin Microspheres versus Polyvinyl Alcohol Microspheres
Section snippets
Study Design
This was a prospective, randomized study that received approval from our institutional review board before study initiation. All patients were first seen within our outpatient interventional radiology office, where they were evaluated for the UAE procedure. As part of our routine UAE protocol, all patients were evaluated with pelvic MR imaging before it was determined whether they were candidates for the procedure. The uterus was measured on this study and volume was calculated according to the
Results
During the study period, a consecutive group of 64 patients were evaluated for participation in this study over a 6-month period of time. A total of 53 patients were successfully enrolled in the study. Eleven patients were not enrolled in the study for reasons that included the presence of adenomyosis without fibroid tumors (n = 3), claustrophobia precluding MR imaging (n = 4), and a desire to not participate in a research study (n = 4). One of these patients signed the research consent but
Discussion
The choice of an embolic agent for use during UAE is one that has been under scrutiny of late. This issue did not exist when UAE was first introduced. Particulate PVA was the initial agent used for this procedure, and its success in addressing the symptoms of a patient with uterine leiomyomas and decreasing uterine and tumor volume has been well documented (14, 15, 16, 17, 18). For several years, there was a uniform approach to UAE by most interventional radiologists because there was virtual
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2018, Journal of the Mechanical Behavior of Biomedical MaterialsCitation Excerpt :For instance, in Table 4 it is clear from the comparison of the products tested by both Lewis 2006 and Forster 2010 that the modulus of Contour SE seems significantly lower than the other embolic microspheres tested, which may raise questions about this products behaviour in vivo. Indeed, the clinical literature reported of the difficulties experienced with the use of this product with inadequate devascularisation as a result of its softness, lack of shape recovery and more distal migration (Spies et al., 2005; Siskin et al., 2008). For LC Bead LUMI™, the increase in density of the product due to the attachment of the iodine to the structure means that the mechanical properties are increased and the compressive modulus is significantly higher than any of the currently-available embolic microspheres (Table 3).
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G.P.S. has received research grants from Boston Scientific Corporation and Biosphere Medical Corporation.