Short communication
Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish

https://doi.org/10.1016/j.jphs.2016.05.009Get rights and content
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Abstract

Age-related macular degeneration (AMD) is a major cause of irreversible loss of central vision in the elderly. Zebrafish is an attractive animal model in some respects, lower cost, smaller housing facilities and easier genetic manipulation compared to rodents. The present study aimed to establish a drug evaluation method against light irradiation, as a dry AMD disease model, using adult pigmented zebrafish. Intravitreal administration of an antioxidant, N-acetylcysteine, protected against light-induced retinal degeneration in a concentration-dependent manner. We established a new drug evaluation model against light-induced retinal degeneration that can provide new knowledge about dry AMD pathology and therapy.

Keywords

Dry age-related macular degeneration
Pigmented retina
Zebrafish

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Peer review under responsibility of Japanese Pharmacological Society.