Letter to the editor
Prelabor cesarean section bypasses natural immune cell maturation

https://doi.org/10.1016/j.jaci.2015.04.044Get rights and content

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Cited by (18)

  • Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier

    2016, Current Opinion in Immunology
    Citation Excerpt :

    Questions are raised whether this risk is any different in elective versus post-labor C-sections, as the process of labor may ‘stress’ the immune system and form the first signal to drive immune activation [56]. A recent study suggested that in addition to the mode of delivery also the gestational age was contributing to immune maturation of circulating cord blood cells [57]. It was hypothesized that neonatal immune maturation is influenced by maternal hormonal changes that normally initiate labor.

  • Influence of the delivery modus on subpopulations and replication of lymphocytes in mothers and newborns

    2015, Early Human Development
    Citation Excerpt :

    Cesarean delivery has been associated with a delayed and dysbalanced intestinal colonization in newborns [43–45] and an increased risk of asthma [46] and other immune diseases [47,48]. However, in newborns delivered by CS, risk of chronic immune disease may be a function of both, immune-dysregulation caused by a disturbed gut microbiota and lack of labor-associated stress factors programming immune functions [49,50]. In our study, lower cytokines, such as IL-2 and IFN-γ, important for effector and regulatory T cell functions, may cause modulation of the immune system towards an immune phenotype at risk for chronic immune diseases, such as allergies or autoimmune disorders.

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COPSAC is funded by private and public research funds all listed on www.copsac.com. The Lundbeck Foundation (grant no. R16-A1694), the Danish Ministry of Health (grant no. 903516); the Danish Council for Strategic Research (grant no. 0603-00280B); the Danish Council for Independent Research (grant no. 10-082884; 271-08-0815) and the Capital Region Research Foundation (no grant numbers) have provided core support for COPSAC. The funding agencies did not have any influence on study design, data collection and analysis, decision to publish, or preparation of the manuscript. No pharmaceutical company was involved in the study. The funding agencies did not have any role in design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript.

Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.

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