Systematic ReviewClinical PathologyTreatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review
Section snippets
Materials and methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied for this review.61 PRISMA comprises a 27-item checklist and a four-phase flow diagram that relates to the title, abstract, introduction, methods, results, and discussion sections of articles, and funding. They were developed based on recommendations regarding what should be included in an accurate and complete report of systematic reviews and meta-analyses.
The systematic search covered the
Results
The results of the literature search are presented in a flow chart, showing study selection according to the PRISMA statement (2009)61 (Fig. 1). The initial search strategy yielded 1355 titles/abstracts from the databases analyzed: 1085 from PubMed, 235 from Web of Science, and 35 from the Cochrane Library; five additional articles were identified through a hand search of the relevant reference lists, bringing the number of accepted articles to 1360. After title and abstract screening and/or
Discussion
The aim of this systematic review was to summarize the literature concerning patients receiving BPs, the treatments of BRONJ, and the outcomes of these treatments. There was high clinical heterogeneity among the studies included, which is unsurprising given the differing interventions used and the considerable variations in techniques applied and combinations or delivery of interventions. Differences in the search periods may explain the higher prevalence of BRONJ in the present review.
There
Funding
No source of funding.
Competing interests
The authors indicate no potential conflicts of interest.
Ethical approval
No human subjects were involved.
Patient consent
Not required.
Acknowledgement
The authors would like to thank Dr Cvetan Popov for his help in the preparation of the manuscript.
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