International Journal of Oral and Maxillofacial Surgery
Research Paper
Dental ImplantsThe influence of recombinant human BMP-2 on bone–implant osseointegration: biomechanical testing and histomorphometric analysis
Dental Implants
Section snippets
Implant preparation
Thirty-two 5.5-mm-long, commercially pure, titanium-roughened, screw-type implants with diameter of 3.3 mm (Northwest Institute for Non-ferrous Metal Research, Baoji, China) were used. The implants were coated with polylactic acid membrane (L/DL 70/30, inherent viscosity 3.3 dl/g, provided by Wuhan University of Technology, China) and divided into two equal groups. Group A was soaked in 2 ml sterile water containing 1.0 mg rhBMP-2 (kindly provided by the Forth Military Medical University); group B
Mechanical pull-out testing and SEM examination
No animal died during the postoperative period. Pull-out testing demonstrated that the binding strength of group A was 36.5 ± 2.02N, which was statistically greater (P < 0.05) than that of group B, 27.63 ± 1.31N (Table 1). SEM images of the extracted implants showed extensive mineralized matrixes on the surface of the group A implants (Fig. 1), compared with the group B implants (Fig. 2).
Confocal laser scanning microscopy
New bone formation was determined histomorphometrically by bone marker quantification, which represented the
Acknowledgement
This investigation was supported by National Natural Science Fund of China (No.39970800).
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Calcium phosphate-based materials regulate osteoclast-mediated osseointegration
2021, Bioactive MaterialsCitation Excerpt :Thus, 1.67CPC could significantly promote osteoclast differentiation and effectively enhance the expression level of TGF-β1 compared to other groups. Osseointegration in bone regeneration is crucial in preventing implant failure and strengthening its function [45–47]. Previous studies have shown improved in vitro bioactivity of scaffolds can enhance osseointegration [45].
Proteins and peptides coatings on the dental implant surface
2020, Dental Implants: Materials, Coatings, Surface Modifications and Interfaces with Oral TissuesNovel strategy for mechanically tunable and bioactive metal implants
2015, BiomaterialsCitation Excerpt :Various materials such as poly-DL-lactic acid scaffolds, nanofibrous chitosan membrane, polylactide/glycolide polymers, and nanohydroxyapatite/collagen/poly-L-lactic acid scaffolds have been used as BMP carriers [52–55]. In previous studies, BMPs have been incorporated into implants in various ways: infused in titanium sponges, covalently bonded through chromosulfuric acid treatment, impregnated in hydroxyapatite plasma-sprayed around implants, and soaked in polylactic acid membranes [17,56–58]. In this work, porous titanium has been selected as a BMP-2 carrier where rhBMP-2 was loaded into the pores and the pore structure was further modified through densification for sustained release of rhBMP-2.
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