Clinical researchAssociation Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents
Section snippets
Study population
Ninety-three obese children with NAFLD aged 6-17 years, 307 obese children without NAFLD, and 150 age- and sex-matched healthy control subjects, were included in the study. NAFLD was diagnosed with abdominal ultrasonography. Obese children who were already being followed by the Pediatric Endocrinology Outpatient Clinic were consecutively enrolled in this study. The control subjects were recruited from a population of nonobese healthy children and adolescents who were admitted to our hospital
Subject characteristics
Of 400 obese children, 93 (23.25%) were diagnosed as NAFLD (67 in group 2 and 26 in group 3). The demographic and laboratory characteristics of the study population are summarized in Table 1. Among all obese children type 2 diabetes was determined in 0.25% (n = 1) and impaired oral glucose tolerance test in 12% (n = 48). Also, the prevalence of hypertension in children with NAFLD was 15.87% (11 cases) for group 2 and 17.76% (5 cases) for group 3, and 15.76% (48 cases) in obese subjects without
Discussion
Several studies in adults and some in children have demonstrated that NAFLD is the primary hepatic complication of obesity and insulin resistance, and may be considered as the early hepatic manifestation of obesity and also metabolic syndrome.2, 4, 8 In this big cohort of study, we showed subclinically impaired cardiac functions in obese children with NAFLD. Also, we evaluated cardiovascular risk and associated parameters with grades of nonalcoholic liver steatosis in obese children with NAFLD.
Disclosures
The authors have no conflicts of interest to disclose.
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2023, Current Problems in CardiologyCitation Excerpt :A more recent study suggested that NAFLD and advanced liver fibrosis, as estimated by fibrosis risk scores is common in patients with HFpEF, however, there is a limited independent association between liver fibrosis risk scores and clinical outcomes related to HF events.30 Numerous studies have reported early systolic and diastolic dysfunction in adults and/or children with NAFLD.27,31-34 Zhang et al. reported 36.3% prevalence of NAFLD defined by ultrasonography in 102 patients with HFrEF.1
Non-alcoholic fatty liver disease in children and adolescents: Lifestyle change - A systematic review and meta-analysis
2018, Annals of HepatologyCitation Excerpt :The gold standard for the diagnosis of NAFLD is histology obtained using liver biopsy, which can determine the presence of steatosis, inflammation or fibrosis.2 The biopsy has some limitations; therefore, indirect methods have been used for diagnosis.7 –10
Comparison of the Phenotype and Approach to Pediatric vs Adult Patients with Nonalcoholic Fatty Liver Disease
2016, GastroenterologyCitation Excerpt :However, some data are controversial. Manco et al92 reported no association between intima-media thickness and liver histology in obese children and adolescents with NAFLD and more recent studies based on surrogate biomarkers of NAFLD or liver biopsy found an increased interventricular septum thickness at end diastole and at end systole.93,94 However, both adult and pediatric studies have shown that NAFLD has been associated with impaired left ventricular function and adverse changes in cardiac geometry, which are well-established risk factors for cardiovascular events.95,96
Quantification of liver fat: A comprehensive review
2016, Computers in Biology and MedicineCitation Excerpt :Microsteatosis is usually more severe than simple steatosis and associated with toxin-induced injury, acute viral and metabolic abnormalities [4]. Macrosteatosis is generally associated with diabetes, dyslipidemia, obesity, alcohol abuse and hyperlipidemia since it affects determination of insulin resistance (i.e.,interfering insulin signaling) and also increases risk of cardiac complications and cardiovascular disease mortality [8–18]. The majority of fatty livers are related to NAFLD (Section 1.1).
Interplay between epicardial adipose tissue, metabolic and cardiovascular diseases
2018, Clinica e Investigacion en Arteriosclerosis
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