Cell
Volume 146, Issue 3, 5 August 2011, Pages 421-434
ArticleRecruitment of Actin Modifiers to TrkA Endosomes Governs Retrograde NGF Signaling and Survival
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Graphical Abstract
Highlights
► Proteomic analysis of endosomes containing the neurotrophin receptor TrkA ► TrkA endosomes associate with actin-modulatory proteins ► Retrograde transport of TrkA endosomes is dependent on F-actin breakdown ► The neurotrophin NGF, but not NT3, can bind TrkA to signal at endosomal pH
Cited by (0)
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These authors contributed equally to this work
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Present address: Department of Pharmacology, University of Washington Medical Center, Seattle, WA 98195, USA
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Present address: Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Present address: Howard Hughes Medical Institute, Smilow Neuroscience Program, New York University School of Medicine, New York, NY 10016, USA
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