Cell
Volume 128, Issue 1, 12 January 2007, Pages 9-13
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Commentary
A Mouse for All Reasons

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Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse embryonic stem (ES) cells. Although the current emphasis is on production of this valuable resource, there are significant efforts to facilitate program coordination, to enhance the availability of this resource, and to plan for future efforts in mouse genetics research.

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1

Communicating authors: Francis S. Collins, National Human Genome Research Institute, National Institutes of Health, USA; Janet Rossant, Hospital for Sick Children, University of Toronto, Canada; Wolfgang Wurst, GSF-National Research Center for Environment and Health, Technical University, Munich, Germany

2

For a full list of International Mouse Knockout Consortium members, please see http://www.cell.com/cgi/content/full/128/1/9/DC1/.

Corresponding author: [email protected]