Original article: general thoracicSurgical Treatments for Multiple Primary Adenocarcinoma of the Lung
Section snippets
Patients and Methods
From January 1994 to December 2002, 517 patients underwent pulmonary resection for non-small cell lung cancer at the National Shikoku Cancer Center (Ehime, Japan). All patients underwent preoperative examinations including plain chest roentgenogram, HRCT of the chest, ultrasonography of the upper abdomen, magnetic resonance imaging of the brain, and bone scintigraphy. There were 369 patients with adenocarcinoma, 111 with squamous cell carcinoma, 19 with adenosquamous carcinoma, 15 with large
Results
Thirty-one patients exhibited primary multiple adenocarcinomas; that corresponded to 8.4% of the total 369 adenocarcinoma patients who underwent surgical resection during the same period. There were 12 males and 19 females with a median age of 68.1 years (range, 47–81). Thirteen patients (41.9%, 11 male and 2 female) exhibited a history of smoking. The incidence of primary multiple adenocarcinomas was substantially higher in female and nonsmokers than that of other histologic multiple lung
Comment
In our retrospective study, 7.9% of surgically resected non-small cell lung cancers and 8.4% of adenocarcinomas exhibited multiple lesions. The incidence of multiple primary lung cancer in our study was comparable with that in previous studies that reported an incidence of 1%–10% 9, 15, 16. However a higher incidence of multiple synchronous adenocarcinomas was a marked characteristic of our series compared with previous reports 8, 10, 17, 18. Even if our study exhibits a limitation of a short
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