Original articleElectrical Impedance Myography in the Assessment of Disuse Atrophy
Section snippets
Subjects
Ten otherwise healthy subjects (6 men, 4 women), ranging in age from 20 to 52 years, with distal leg and foot fractures requiring cast immobilization were recruited consecutively from the orthopedic surgery department at Beth Israel Deaconess Medical Center. All subjects were treated nonoperatively in below-knee casts that consisted of the serial application of a 4-inch stockinette,a followed by 4 to 6 rolls of Webril undercast padding,b and then 4 rolls of 10cm × 3.6m Delta Lite fiberglass
Results
Table 1 lists patient characteristics including the durations of immobilization (I1) and time between serial EIM measurements (I2).
Discussion
Disuse atrophy is an important phenomenon with health consequences that are potentially of great magnitude. A noninvasive method to quantify disuse atrophy could be helpful in monitoring rehabilitation efforts in patients with orthopedic injuries,15 assessing sarcopenia of aging,16, 17, 18 and planning adaptive countermeasures for microgravity environments.6, 7 Unfortunately, the methods used thus far are not ideal for the clinical study of disuse atrophy, as they are invasive, inconsistent, or
Conclusions
EIM may be a powerful tool for the assessment of disuse atrophy. Further study to verify these results in a larger population of patients with disuse atrophy from a variety of conditions is indicated.
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Supported by the National Institutes of Health, National Institute of Neurological Disorders and Stroke (grant nos. F32 NS055583-01A1, R01 NS042037).
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.