Sistemic sclerosis is a connective tissue disease with cutaneous involvement.
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Digital ulcers involve hands, feet, bony prominence and lower limbs.
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Skin is the window of the disease: if skin conditions worsen, an aggravation of systemic involvement can be suspected.
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Fat grafting represents an innovative technique promoting a faster wound healing.
Abstract
Systemic sclerosis is a connective tissue disease with cutaneous involvement. Clinical manifestations result from the balance of inflammations/autoimmunity process and fibrogenesis. Patients suffer from skin ulcers, non-ulcerative lesions including digital pitting scars, telangiectasias, subungual hyperkeratosis, abrasions, fissures, and subcutaneous calcinosis. A review about the pathophysiology of the disease, the physical examination of the patients, the instrumental assessment, and possible treatments is performed.
