AJM onlineBrief observationTroponin I Levels in Patients with Preeclampsia
Section snippets
Methods
Between November 2003 and March 2005, blood samples were obtained at the time of admission to delivery from patients with and without preeclampsia. The diagnosis of preeclampsia was based on standard criteria as outlined in the Technical Bulletin from the American College of Obstetrics and Gynecology on hypertension in Pregnancy.7 The control group was composed of patients not meeting criteria for preeclampsia, as well as healthy controls. The study was approved by the institutional review
Results
There were 39 women included (20 with preeclampsia and 19 without). Baseline characteristics of the 2 groups are summarized in the Table. Mean troponin I level was 0.008 ng/mL in patients with preeclampsia and 0.01 ng/mL in controls (P = .59) (Table). The highest troponin I level was 0.04 ng/mL for patients both with and without preeclampsia, occurring in only 1 patient in each group.
Discussion
Despite hypertension and the presence of an inflammatory state, troponin I was not found to be elevated in patients with preeclampsia. Although preterm delivery in a mother with preeclampsia is predictive of future late cardiovascular death,8 and population-based studies have shown increased long-term maternal risk with hypertension related to pregnancy,6, 9 the lack of troponin elevation at the time of delivery in our patient series does not support the occurrence of acute myocardial damage.
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Cited by (48)
Coronary Events in the Pregnant Patient: Who Is at Risk and How Best to Manage?
2021, Canadian Journal of CardiologyCitation Excerpt :Cardiac biomarkers such as troponin are usually within the normal range immediately after delivery, however, high sensitivity assays can be elevated in up to 4% of asymptomatic women.60 Pre-eclampsia and gestational hypertension are also associated with abnormal troponin elevations, in the absence of other markers of cardiac ischemia.61 The use of beta-mimetic tocolysis has been shown to elevate troponin T levels in one study.62
Pregnancy and Cardiovascular Disease
2021, Sex Differences in Cardiac Diseases: Pathophysiology, Presentation, Diagnosis and ManagementUrinary troponin concentration as a marker of cardiac damage in pregnancies complicated with preeclampsia
2020, Medical HypothesesCitation Excerpt :Previous studies that did not found association between preeclampsia related hemodynamic changes and elevated levels of serum troponin were largely conducted on a small sample size [27]. Most of the studies which reported this association aimed to investigate levels of troponin I, while levels of TnT were not analyzed [26–29]. Ravichandran first reported results of study assesing serum cardiac troponin I using a high-sensitivity assay in pregnancies complicated with hypertensive disorder.
High-Sensitivity Cardiac Troponin I Levels in Normal and Hypertensive Pregnancy
2019, American Journal of MedicineHigh sensitivity cardiac troponin I levels in preeclampsia
2018, Pregnancy HypertensionTroponin i in preeclampsia and eclampsia
2015, Progresos de Obstetricia y Ginecologia