ORIGINAL ARTICLESOnset of Action, Efficacy, and Safety of a Single Dose of Fexofenadine Hydrochloride for Ragweed Allergy Using an Environmental Exposure Unit
REFERENCES (10)
- et al.
Efficacy and safety of Fexofenadine HCL in fall seasonal allergic rhinitis [Abstract]
J Allergy Clin Immunol
(1996) - et al.
Fexofenadine: a new non-sedating antihistamine is effective in the treatment of seasonal allergic rhinitis [Abstract]
J Allergy Clin Immunol
(1996) - et al.
Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure
Ann Allergy Asthma Immunol
(1996) - et al.
A randomized, double-blind, placebo-controlled antigen delivery study of the onset of action of aerosolized tri-amcinolone acetonide nasal spray in subjects with ragweed-induced allergic rhinitis
J Allergy Clin Immunol
(1996) - et al.
Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
Clin Pharmacol Ther
(1992)
Cited by (91)
Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber
2011, Allergology InternationalStructural and clinical impact of anti-allergy agents: An overview
2020, Bioorganic ChemistryTherapeutic effect of bilastine in Japanese cedar pollinosis using an artificial exposure chamber (OHIO Chamber)
2017, Allergology InternationalCitation Excerpt :ii) The manifestation of the nasal symptoms on Day 1 could be prompted to occur earlier by performing the priming exposure on Day −1. ( iii) The onset of action of BIL and FEX was expected to occur approximately 60 min after dosing.18,21 ( iv) The efficacy assessment of study drugs has usually been performed following a 3-h pollen exposure in our previous EEC studies.9,10,13 (
Environmental exposure unit: A sensitive, specific, and reproducible methodology for allergen challenge
2013, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Fexofenadine is the active metabolite of terfenadine, considered a third-generation antihistamine. One of the first published trials of its efficacy was conducted in the EEU.47 Two different doses of fexofenadine (60 and 120 mg) were compared with placebo and provided clinically important relief of allergic rhinitis symptoms, with a median time to onset of 60 minutes.47
Antihistamine Therapy in Allergic Rhinitis
2011, Immunology and Allergy Clinics of North America
Financial support for this study was provided by Nordic Merrell Dow Research, Inc.