Heterochromatin and gene regulation in Drosophila
References (65)
Gene number, noise reduction, and biological complexity
Trends Genet
(1995)- et al.
Sixty years of mystery
Genetics
(1990) - et al.
Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect
Genetics
(1988) - et al.
Silencers and domains of generalized repression
Science
(1994) - et al.
Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos
J Cell Sci
(1995) Das heterochromatin der Moose
I Jehrb Wiss Botanik
(1928)Role of replication time in the control of tissue-specific gene expression
Am J Hum Genet
(1987)- et al.
Epigenetic regulation in mammals
Position-effect variegation in Drosophila
- et al.
Heterochromatin and gene expression in Drosophila
Annu Rev Genet
(1995)
Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster. I. Morphology and genetic activity of the 2AB region in chromosome rearrangement T(1;2)dorvar7
Chromosoma
Silencing and heritable domains of gene expression
Annu Rev Genet
Overcoming telomeric silencing; a transactivator competes to establish gene expression in a cell cycle-dependent way
Genes Dev
Epigenetic regulation in Drosophila: a conspiracy of silence
Chromatin multiprotein complexes involved in the maintenance of transcription patterns
Curr Opin Genet Dev
A possible role of “inert” heterochromatin in cell differentiation. Action and competition for “locking” molecules
Biochemie
The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster
Genetics
Functional elements in Drosophila melanogaster heterochromatin
Annu Rev Genet
The effect of modifiers of position effect variegation on the variegation of heterochromatic genes of Drosophila melanogester
Genetics
Cis-effects of heterochromatin on heterochromatic and euchromatic gene activity in Drosophila melanogaster
Genetics
Transposable elements are stable structural components of Drosophila melanogaster heterochromatin
Proc Natl Acad Sci USA
Transposable elements map in a conserved pattern of distribution extending from β-heterochromatin to centromeres in Drosophila melanogaster
Chromosoma
Islands of complex DNA are widespread in Drosophila centric heterochromatin
Genetics
Insertional mutagenesis of Drosophila heterochromatin with single P-elements
Proc Natl Acad Sci USA
The Drosophila salivary gland chromocenter contains highly polytenized subdomains of mitotic heterochromatin
Genetics
The organization and expression of the light gene, a heterochromatic gene of Drosophila melanogaster
Genetics
Drosophila telomeres; another way to end it all
Transposition of the LINE-like retrotransposon TART to Drosophila chromosome termini
Proc Natl Acad Sci USA
Structure of the Drosophila HeT-A transposon: a retrotransposon-like element forming telomeres
Chromosoma
Studies of het DNA sequences in the pericentric regions of Drosophila chromosomes
Chromosoma
The Drosophila telomere transposon HeT-A produces a transcript with tightly bound protein
Proc Natl Acad Sci USA
Position-effect variegation—an assay for nonhistone chromosomal proteins and chromatin assembly and modifying factors
Cited by (200)
The impact of histone post-translational modifications in neurodegenerative diseases
2019, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The basic unit of chromatin is called a nucleosome, consisting of a histone octamer comprising two copies of each of the core histone proteins (H2A, H2B, H3, and H4) around which DNA wraps [64]. Depending on how tightly associated the DNA is to the histone core, there is tightly packaged heterochromatin, or loosely packaged euchromatin [65]. Heterochromatin is transcriptionally silent, while euchromatin is actively transcribed [66].
Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
2019, Current Opinion in Genetics and DevelopmentCitation Excerpt :Subsequently, heterochromatin was observed to fall into two distinct categories: constitutive, compacted genomic areas formed in many cell types at centromeres and telomeres; and facultative, locus-specific or cell type-specific heterochromatin [1]. Constitutive heterochromatin typically marks repeat-rich sequences and prevents recombination of conserved genomic portions between chromosomes (Figure 1), while facultative heterochromatin is thought to silence expression of cell type-inappropriate protein-coding genes [2,3]. For comprehensive reports, see two recent reviews on heterochromatin structure and function [4,5].
Computational Methods for Assessing Chromatin Hierarchy
2018, Computational and Structural Biotechnology JournalH3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation
2015, Molecular CellCitation Excerpt :By contrast, the majority of H3K9me3 is associated with “constitutive” heterochromatin at telomeres and centromeres, while H3K9me3 of the inactive X chromosome in female forms facultative heterochromatin (Peters et al., 2002). In Drosophila, when a gene normally in euchromatin is re-localized close to or within constitutive heterochromatin by rearrangement or transposition, the gene becomes transcriptionally silenced, giving a phenomenon known as position-effect variegation (PEV) (Elgin, 1996). Similar to this, lineage-specific intragenic H3K9me3 shown in the current study could generate a unique euchromatin/heterochromatin border within a single gene (e.g., Cebpa and Pparg) at its natural chromosomal position.
Ultramicroscopic examination of mature massulae of Habenaria arinaria (Orchidaceae)
2015, MicronCitation Excerpt :Quite contrary to previous known, however, the present study demonstrated a high level of chromatin condensation in the vegetative nucleus in the massula of H. arinaria. It is a common knowledge that gene expression seldom occurs in highly condensed chromatin (Elgin, 1996; van Steensel, 2011; Luger et al., 2012). Therefore, the vegetative nucleus in the massula of H. arinaria is believed to enter a quiescent state during pollen maturation.