Cellular diversification in the vertebrate retina

https://doi.org/10.1016/S0959-437X(97)80013-5Get rights and content

Abstract

The discovery of heterogeneous populations of retinal precursors with sequentially modified fates may help solve the conundrum of conserved histogenesis in the absence of determination either by birthdate or lineage. Combined with a wealth of new data on the exogeneous and endogenous factors that influence cellular fate in the retina, models of how complexity is generated are beginning to emerge.

References (62)

  • SE Brockerhoff et al.

    A behavioral screen for isolating zebrafish mutants with visual system defects

    Proc Natl Acad Sci USA

    (1995)
  • ML Allende et al.

    Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development [see comments]

    Genes Dev

    (1996)
  • P Haffter et al.

    The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio

    Development

    (1996)
  • J Malicki et al.

    Mutations affecting development of the zebrafish retina

    Development

    (1996)
  • Y Kikuchi et al.

    Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the islet-3 LIM/homeodomain protein

    Neuron

    (1997)
  • R Adler

    Determination of cellular types in the retina

    Invest Ophthalmol Vis Sci

    (1993)
  • TA Reh et al.

    Intrinsic and extrinsic signals in the developing verterbrate and fly eyes: viewing vertebrate and invertebrate eyes in the same light

    Perspect Dev Neurobiol

    (1994)
  • S Huang et al.

    The retinal fate of Xenopus cleavage stage progenitors is dependent upon blastomere position and competence: studies of normal and regulated clones

    J Neurosci

    (1993)
  • S Huang et al.

    Asymmetrical blastomere origin and spatial domains of dopamine and neuropeptide Y amacrine subtypes in Xenopus tadpole retina

    J Comp Neurol

    (1995)
  • MR Alexiades et al.

    Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny

    Development

    (1997)
  • AF Mack et al.

    New rods move before diffentiating in adult teleost retina

    Dev Biol

    (1995)
  • DH Rapaport et al.

    Spatiotemporal gradients of cell genesis in the primate retina

    Perspect Dev Neurobiol

    (1996)
  • T Belecky Adams et al.

    Correlations between terminal mitosis and differentiated fate of retinal precursor cells in vivo and in vitro: analysis with the ‘window-labeling’ technique

    Dev Biol

    (1996)
  • F Hallbook et al.

    Expression of neurotrophins and trk receptors in the avian retina

    J Comp Neurol

    (1996)
  • P Bovolenta et al.

    Neurotrophin-3 antibodies disrupt the normal development of the chick retina

    J Neurosci

    (1996)
  • M Kirsch et al.

    Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: expression of CNTF and its receptors and in vitro effects on target cells

    J Neurochem

    (1997)
  • ZD Ezzeddine et al.

    Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina

    Development

    (1997)
  • S Fuhrmann et al.

    Ciliary neurotrophic factor promotes chick photoreceptor development in vitro

    Development

    (1995)
  • M Kirsch et al.

    CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors

    Neuroreport

    (1996)
  • MW Kelley et al.

    Regulation of proliferation and photoreceptors differentiation in fetal human retinal cell cultures

    Invest Ophthalmol Vis Sci

    (1995)
  • C Pittack et al.

    Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos

    Development

    (1997)
  • Cited by (144)

    • A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation

      2021, iScience
      Citation Excerpt :

      The division of RSCs is heterogeneous in vivo; they undergo a variable number of divisions producing clones with different sizes and cell type compositions. The apparent randomness of clonal size and cell fate distribution suggested a strong element of stochasticity (Cayouette et al., 2003; Cepko, 2014; Fekete et al., 1994; Harris, 1997; He et al., 2012; Trimarchi et al., 2008; Turner and Cepko, 1988; Wetts and Fraser, 1988). Downstream retinal progenitor cells pass through a series of competence states to produce all retinal cell types.

    • Analysis of expression of transcription factors in early human retina

      2017, International Journal of Developmental Neuroscience
      Citation Excerpt :

      The optic vesicle gives rise to pigmented and ciliary epithelia, as well as the neural retina (NR). By coordinating extrinsic and intrinsic factor, the retinal progenitor cells (RPCs) in the NR generate ganglion cells, horizontal interneurons, cone photoreceptors, amacrine interneurons, rod photoreceptors, bipolar interneurons and Müller glia (Harris, 1997; Livesey and Cepko, 2001; Marquardt and Gruss, 2002). These processes are controlled by multiple homeodomain and basic helix-loop-helix (bHLH) genes (Cepko, 1999; Hutcheson and Vetter, 2001; Hatakeyama et al., 2001).

    • Spatial and temporal expressions of prune reveal a role in Müller gliogenesis during Xenopus retinal development

      2012, Gene
      Citation Excerpt :

      All of these retinal cell types are generated from a single sheet of neuro-epithelial cells as they differentiate in a specific temporal pattern (Ohnuma et al., 2002b). The identity of retinal neurons and glial cells is determined by the repertoire of intrinsic factors that are expressed by retinal precursor cells, as well as by extrinsic signals in the environment (Cepko et al., 1996; Edlund and Jessell, 1999; Harris, 1997). The development of this stratified retinal cell architecture is largely conserved in all vertebrates, which implies that a common fundamental mechanism is involved in the generation of these retinal cell types.

    View all citing articles on Scopus
    View full text