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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

Published online by Cambridge University Press:  16 April 2020

Petra Franke ,
Birgit Wendel ,
Michael Knapp ,
Sibylle G. Schwab ,
Daniela Neef ,
Wolfgang Maier ,
Dieter B. Wildenauer  and
Margret R. Hoehe
Petra Franke*
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105Bonn, Germany
Birgit Wendel
Affiliation:
Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany
Michael Knapp
Affiliation:
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Sibylle G. Schwab
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105Bonn, Germany
Daniela Neef
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105Bonn, Germany
Wolfgang Maier
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105Bonn, Germany
Dieter B. Wildenauer
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105Bonn, Germany
Margret R. Hoehe
Affiliation:
Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany Max Planck Institute for Molecular Genetics, Berlin, Germany
*
*E-mail address: petra.franke@ukb.uni-bonn.de
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Abstract

Objective. –

In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human μ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence.

Methods. –

In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the “Dangerous Drugs Act” in Germany.

Results. –

For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence.

Conclusions. –

Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.

Keywords

AddictionOpioidsOPRM1PolymorphismCase–control study
Type
Original article
Information
European Psychiatry , Volume 18 , Issue 1 , February 2003 , pp. 18 - 22
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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