Molecular characterization of the Salmonella typhi StpA protein that is related to both Yersinia YopE cytotoxin and YopH tyrosine phosphatase

https://doi.org/10.1016/S0923-2508(97)81896-7Get rights and content
Under an Elsevier user license
open archive

Summary

Analysis of the nucleotide sequence of a 4-kb DNA fragment located between the sip and iag loci on Salmonella typhi chromosome revealed three open reading frames, termed sipF, ctpA and stpA. The 82-amino-acid (aa) sipF product showed extensive similarity to the lacP protein from S. typhimurium. The StpA protein (535 aa) exhibited significant similarity to both Yersinia enterocolitica YopE cytotoxin and YopH tyrosine phosphatase. The CtpA polypeptide (130 aa) might be the molecular chaperone of the StpA protein.

Key-words

Virulence
Chaperone
ORF
Tyrosine phosphatase YopH
Cytotoxin YopE
Salmonella typhi
Protein StpA
Nucleotide sequence
sipA
sipF
stpA
S. typhimurium
Yersinia

Cited by (0)