DDE-induced eggshell thinning in birds: Effects of p,p′-DDE on the calcium and prostaglandin metabolism of the eggshell gland

doi:10.1016/S0742-8413(97)00105-9

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

Volume 118, Issue 2, October 1997, Pages 113-128

https://doi.org/10.1016/S0742-8413(97)00105-9 Get rights and content

Abstract

1.
1. The focus of this review is the effects and mechanism of action of p,p′-DDE on eggshell formation in birds. Inhibition of prostaglandin synthesis in the eggshell gland mucosa is a probable mechanism for p,p′-DDE-induced eggshell thinning.
2.
2. The duck is sensitive to p,p′-DDE-induced eggshell thinning but the domestic fowl is not, and studies comparing the two species in regard to the calcium and prostaglandin metabolism of the eggshell gland have shown that eggshell thinning induced by p,p′-DDE in ducks is accompanied by reduced activity of prostaglandin synthetase, reduced levels of prostaglandin E₂, and reduced uptake of ⁴⁵Ca by the eggshell gland mucosa. The content of calcium, bicarbonate, chloride, sodium, and potassium are also reduced in the eggshell gland lumen in ducks exhibiting eggshell thinning. None of these effects are seen in the domestic fowl.
3.
3. Inhibition of prostaglandin synthesis is a specific effect of p,p′-DDE. The detrimental effects of p,p′-DDE on the eggshell gland seem to be unique when comparing the compound with structurally related substances, i.e., similar treatment regimens with o,p′-DDE, p,p′-DDT, o,p′-DDT, and p,p′-DDD do not cause eggshell thinning in ducks. Neither do they inhibit prostaglandin synthesis in the eggshell gland mucosa.
4.
4. Administration of other compounds that do inhibit prostaglandin synthesis, e.g., indomethacin, does cause the same effects as those seen with p,p′-DDE, i.e., eggshell thinning and the described effects on the calcium and prostaglandin metabolism of the eggshell gland.

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Citation Excerpt :
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ReviewDDE-induced eggshell thinning in birds: Effects of p,p′-DDE on the calcium and prostaglandin metabolism of the eggshell gland

Abstract

Poult. Sci.

Gen. Comp. Endocrinol.

Comp. Biochem. Physiol.

Resp. Physiol.

Toxicology

Toxicology

Poult. Sci.

Environ. Pollut.

Environ. Pollut.

Aquatic Toxicol.

Toxicol. Appl. Pharmacol.

Gen. Comp. Endocrinol.

Comp. Biochem. Physiol.

Prostaglandins

Comp. Biochem. Physiol.

Adv. Pharmacol. Chemotherap.

Gen. Comp. Endocrinol.

Environ. Pollut.

Tox. Appl. Pharm.

Poultry Sci.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Comp. Biochem. Physiol.

Poult. Sci.

Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins

Am. J. Physiol.

Significance of chlorinated hydrocarbon residues to breeding pelicans and cormorants

Canadian Field Naturalist

PGE2 binding, synthesis and distribution in hen oviduct

Am. J. Physiol.

Differential regulation of calbindin D 28 K mRNA in the intestine and eggshell gland of the laying hen

J. Mol. Endocrinol.

The stimulation of chloride transport by prostaglandins and their interaction with epinephrine, theophylline and cAMP in the corneal epithelium

J. Membr. Biol.

Enzymatic changes in the oviduct associated with DDE-induced eggshell thinning in the kestrel Falco sparverius

Bull. Environ. Contam. Toxicol.

Estrogenic activity of o,p′-DDT in mammalian uterus and avian oviduct

Science

DDT induced inhibition of avian shell gland carbonic anhydrase

Science

Measurements of brown pelican eggshells from Florida and South Carolina

Bioscience

Further interpretation of the relation of organochlorine residues in brown pelican eggs to reproductive success

Environ. Pollut.

DDT, DDD and DDE in birds

A review of factors affecting productivity of bald eagles in the Great Lakes region—implications for recovery

Environ. Health. Persp.

Radiographic studies on the formation of the hen's eggshell

J. Exp. Biol.

Toxicity of high dietary levels of DDT in laying hens

Bull. Environ. Contam. Toxicol.

The plight of the American Bald Eagle

Audubon Magazine

Estrogenic action of DDT analogues

Am. J. Ind. Med.

Eggshell thickness in marine birds in the New York Bight 1970s–1990s

Arch. Environ. Contam. Toxicol.

The Avian Egg: Chemistry and Biology

A study of the physical and chemical changes of the egg during its passage through the isthmus and uterus of the hens oviduct

J. Exp. Zool.

Effects of ingested petroleum on the development of ovarian endocrine function in photostimulated mallard ducks

Arch. Environ. Contam. Toxicol.

Review
DDE-induced eggshell thinning in birds: Effects of p,p′-DDE on the calcium and prostaglandin metabolism of the eggshell gland

PGE₂ binding, synthesis and distribution in hen oviduct