Journal of the American Academy of Dermatology
Effects of topical clindamycin on intestinal microflora in patients with acne
References (24)
- et al.
Systemic absorption of clindamycin hydrochloride after topical application
J Am Acad Dermatol
(1982) - et al.
Antibiotic-associated colitis: Implication of a toxin neutralized by C. sordellii antitoxin
Lancet
(1977) - et al.
Clostridium difficile and the aetiology of pseudomembranous colitis
Lancet
(1978) Antibiotic-associated colitis
Antibiotic-associated pseudomembranous colitis
Rev Infect Dis
(1979)- et al.
Clindamycin-associated colitis: A prospective study
Ann Intern Med
(1974) - et al.
Topical clindamycin therapy for acne vulgaris: A cooperative clinical study
Arch Dermatol
(1981) - et al.
Acne vulgaris: Double-blind trial comparing tetracycline and clindamycin
Arch Dermatol
(1976) - et al.
Clindamycin phosphate used in combination with tretinoin in the treatment of acne
Int J Dermatol
(1983) - et al.
Topical clindamycin in acne vulgaris: Safety and stability
Arch Dermatol
(1977)
Pseudomembranous colitis after topical application of clindamycin
Arch Dermatol
Selective and differential medium for isolation of Clostridium difficile
J Clin Microbiol
Cited by (26)
Management of severe acne during pregnancy: A case report and review of the literature
2017, International Journal of Women's DermatologyCitation Excerpt :Studies have shown that a combination of benzoyl peroxide and clindamycin is superior to each case individually and may decrease the risk of antibiotic resistance (Lookingbill et al., 1997). It should be noted that rare reports of Clostridium difficile have been seen with patients who were treated with topical clindamycin (Milstone, 1981; Parry, 1986) although it is unclear if this holds true clinical significance (Siegle et al., 1986). Bacteriostatic azelaic acid exerts broad antimicrobial effects via an unknown mechanism and has a well-documented safety profile during pregnancy (Graupe et al., 1996).
Topical antibacterial agents
2000, Infectious Disease Clinics of North AmericaCitation Excerpt :One potential concern with clindamycin is systemic absorption leading to pseudomembranous colitis. It is estimated that approximately 1% of topical clindamycin phosphate (1% concentration) is absorbed, and there are two case reports of pseudomembranous colitis associated with topical application79; however, two placebo-controlled studies found no increased incidence of diarrhea in patients treated with topical clindamycin compared with placebo.44,95 If there is diminished therapeutic response over time to clindamycin or especially erythromycin, then P. acnes resistance should be considered.88
Clostridium difficile-associated diarrhea after short term vaginal administration of clindamycin
1999, American Journal of GastroenterologyCurrent concepts in the pathogenesis and treatment of acne
1998, Journal of Oral and Maxillofacial SurgeryTransdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data
1998, Journal of the European Academy of Dermatology and VenereologyThe treatment of acne: The role of combination therapies
1995, Journal of the American Academy of Dermatology
Supported by The Upjohn Co., Kalamazoo, MI.