Regular PaperExpression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours
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Cited by (43)
Met as a therapeutic target in HCC: Facts and hopes
2014, Journal of HepatologySignaling networks in human hepatocarcinogenesis-novel aspects and therapeutic options
2010, Progress in Molecular Biology and Translational ScienceCitation Excerpt :While MET is mainly located on cells of epithelial origin, HGF is expressed by cells of mesenchymal origin. Likewise, the ligand is not expressed by tumor cells themselves, but is secreted by stellate cells or myofibroblasts that may stimulate HCC cell invasiveness in an HGF-dependent manner.16,17 HGF is secreted as an inactive proform which is proteolytically cleaved to gain full biological activity.
Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection
2008, European Journal of Surgical OncologyCitation Excerpt :The effects of HGF are mediated by a specific receptor encoded by the c-met protooncogene.23 Increased expression levels of the c-met receptor have been shown in the liver under several human benign and malignant pathologies, including HCC.24 The possible relationship between serum HGF levels and expression of the c-met receptor in HCC tissue remained to be examined.
Hepatocyte growth factor and its receptor, met
2003, The Cytokine Handbook