Mini-reviewThe multidrug transporters—proteins of an ancient immune system
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Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters
2015, Advances in Cancer ResearchCitation Excerpt :The ABCB1 protein transports mostly hydrophobic or positively charged amphipathic molecules, while the substrate specificity of the ABCG2 transporter is even wider and includes entirely hydrophobic toxic compounds, amphiphilic positively or negatively charged, as well as practically water-soluble molecules. Besides their capability of transporting various therapeutic drugs, these MDR-ABC transporters also play an important physiological role in cellular and systemic detoxification and are key members of the xenobiotic or the so-called chemoimmunity defense system of the body (Sarkadi, Homolya, Szakacs, & Varadi, 2006; Sarkadi, Muller, & Hollo, 1996). Besides its general protective role, ABCB1 is currently not known to transport any specific physiological substrates.
Mechanisms for xenobiotic transport in biological membranes
1999, Toxicology LettersChapter 12 Active Transport and Pumps
1999, Current Topics in Membranes and TransportExpression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
1998, Biochemical and Biophysical Research CommunicationsCloning of AtMRP1, an Arabidopsis thaliana cDNA encoding a homologue of the mammalian multidrug resistance-associated protein
1998, Biochimica et Biophysica Acta - Biomembranes