Hereditary diffuse gastric cancer

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Abstract

Hereditary diffuse gastric cancer (HDGC) is a cancer predisposition syndrome caused by germline mutation of the gene for the cell-to-cell adhesion protein E-cadherin. The syndrome is dominated by predisposition to the histologically diffuse, poorly differentiated form of gastric cancer. It is not associated with intestinal-type gastric cancer, but families may have an elevated risk of lobular breast cancer. Here, we review the identified families, mutations, and proposed mechanisms by which E-cadherin loss promotes tumorigenesis.

References (50)

  • A.E. Aplin et al.

    Curr. Opin. Cell Biol.

    (1999)
  • G. Berx et al.

    Genomics

    (1995)
  • G.B. Grunwald

    Curr. Opin. Cell Biol.

    (1993)
  • G. Keller et al.

    Am. J. Pathol.

    (1999)
  • A. Kikuchi

    Biochem. Biophys. Res. Commun.

    (2000)
  • S.H. Kim et al.

    J. Biol. Chem.

    (2000)
  • Q. Meng et al.

    Biochem. Biophys. Res. Commun.

    (2000)
  • S. Pece et al.

    J. Biol. Chem.

    (2000)
  • S. Pece et al.

    J. Biol. Chem.

    (1999)
  • P. Polakis

    Curr. Opin. Genet. Dev.

    (1999)
  • K. Vleminckx et al.

    Cell

    (1991)
  • K.-F. Becker et al.

    Cancer Res.

    (1994)
  • G. Berx et al.

    Oncogene

    (1996)
  • G. Berx et al.

    Hum. Mutat.

    (1998)
  • G. Berx et al.

    Cell Adhesion Commun.

    (1998)
  • K. Borch et al.

    Br. J. Surg.

    (2000)
  • P. Boyle

    Lancet

    (1997)
  • C. Caldas et al.

    J. Med. Genet.

    (1999)
  • P. Correa et al.

    J. Natl. Cancer Inst.

    (1973)
  • E.H. Frixen et al.

    J. Cell Biol.

    (1991)
  • S.A. Gayther et al.

    Cancer Res.

    (1998)
  • D.E. Goldgar et al.

    J. Natl. Cancer Inst.

    (1994)
  • W.M. Grady et al.

    Nature Genet.

    (2000)
  • P. Guilford et al.

    Nature

    (1998)
  • P. Guilford et al.

    Hum. Mutat.

    (1999)

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