Elsevier

Tetrahedron Letters

Volume 39, Issue 30, 23 July 1998, Pages 5401-5404
Tetrahedron Letters

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

https://doi.org/10.1016/S0040-4039(98)01084-3Get rights and content

Abstract

Bicyclic nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneuridine and -cytidine, were incorporated into oligonucleotides, and the binding efficiency of the modified oligonucleotides to the complementary DNA and RNA as well as the CD spectra of the modified DNA-DNA and modified DNA-RNA duplexes were studied.

Bicyclic nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneuridine and -cytidine, were incorporated into oligonucleotides. The melting temperatures and the CD spectra of the modified DNA-DNA and modified DNA-RNA duplexes were studied.

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References (15)

  • SL Beaucage et al.

    Tetrahedron

    (1993)
  • B Hyrup et al.

    Bioorg. Med. Chem.

    (1996)
  • S Obika et al.

    Tetrahedron Lett.

    (1997)
  • AA Koshkin et al.

    Tetrahedron

    (1998)
  • M Scherr et al.

    Bioorg. Med. Chem. Lett.

    (1997)
  • PN Borer et al.

    J. Mol. Biol.

    (1974)
  • E Uhlmann et al.

    Chem. Rev.

    (1990)
There are more references available in the full text version of this article.

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