Conformational studies and stereochemical assignments of the lactarane sesquiterpenes furoscrobiculin D and blennin D

doi:10.1016/S0040-4020(01)80832-2

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Volume 50, Issue 4, 24 January 1994, Pages 1211-1216

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Abstract

Two lactarane, sesquiterpenes, furoscrobiculin D and blennin D, previously isolated from the mushrooms Lactarius scrobiculatus and Lactarius blennius, respectively, have been submitted to conformational analysis by molecular mechanics. The results of the molecular modeling were related to the observed ¹H NMR data and allowed to assign stereostructure 4 to furoscrobiculin D, correcting the previous assignment 1, and stereostructure 5 to blennin D, confirming the previous assignment.

Furoscrobiculin D and blennin D were assigned stereostructures 4 and 5, respectively, by molecular mechanics and ¹H NMR spetroscopy.

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^☆: Communication N. 31 of the series “Fungal metabolites”. For part 30 see Gamba-Invernizzi, A.; Garlaschelli, L.; Rossi, A.; Vidari, G.; Vita-Finzi, P. J. Nat. Prod. 1993, 56, 000.

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Conformational studies and stereochemical assignments of the lactarane sesquiterpenes furoscrobiculin D and blennin D☆

Abstract

Phytochemistry

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