Our understanding of speech and language disorders may be aided by information about the constraints and predispositions contributed by neural developmental processes. As soon as we begin to look at human neuroanatomy and development from a comparative perspective, it is possible to recognize a number of ways that human brains diverge from the general pattern of other ape and monkey brains. These divergences may offer clues to language evolution. Large-scale quantitative changes in the relative proportions of brain regions (as opposed to just overall expansion) offer some of the most obvious clues. Additional information about how axons are guided in their extensions to distant developmental targets and how competitive trophic processes sculpt these connections also provides a way to understand how gross quantitative changes in cell numbers could affect circuit organization and ultimately behavior.