Original ArticlesProbucol Improves Endothelial-Dependent Relaxation and Decreases Vascular Superoxide Production in Cholesterol-Fed Rabbits
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NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition
2008, Pharmacology and TherapeuticsThe new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism
2008, AtherosclerosisCitation Excerpt :We found that DiNAC is a potent modifier of such systems in vivo, an effect that it shared with probucol [16,22]. This is interesting, as probucol is known both to improve endothelial function [23–27], and to have anti-atherosclerotic properties, an effect probably unrelated to its antioxidant properties [28,29]. We therefore tested DiNAC in animal models of atherosclerosis and atherosclerosis related endothelial dysfunction, and found it to be effective in both [22,30].
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