Therapeutic Approaches to Genital Warts
Section snippets
Current Therapies for Genital Warts
Many of the therapies used to treat genital warts have been available for decades. In many cases, the safety and effectiveness of these treatments have not been assessed in well-controlled, prospective clinical trials. Comparative trials of therapies are also relatively rare. The dearth of such information can make it difficult to evaluate the efficacy of different treatment modalities.
Table 1 summarizes selected published data on current genital wart therapies. It should be noted that a number
New Therapies for the Treatment of External Genital Warts
New therapies for genital warts focus on improving delivery of therapeutic agents to genital lesions and stimulating the immune system to combat the virus. These treatments offer exciting options to conventional treatments and may play an important role in future therapeutic decisions.
Prospects for a Vaccine
As a viral disease, HPV infection is a candidate for preventative vaccination.[54]A successful vaccine could potentially reduce the number of cases of HPV-associated genital cancers, particularly cervical malignancies. Current efforts are targeted at the development of prophylactic vaccines to prevent HPV disease and therapeutic vaccines that help boost the host's immune response to HPV-infected cells.
Because HPV cannot be cultured, most attention to date has been focused on the possibility of
Conclusions
A variety of therapies are available for the treatment of genital warts. The best choice of treatment for a given patient depends on the extent and location of disease and the preferences of the clinician and patient.
Current therapies for the treatment of genital warts probably do not eradicate the viral reservoir present in adjacent tissue. Thus, in many cases these treatments are destined to fail, as indicated by the high rate of recurrent infections. Despite the high recurrence rates
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